Perovial® Injections for Penile Curvature
At a Glance
- Condition: Acute-phase Peyronie’s disease (Induratio Penis Plastica)
- Primary Treatment: Perovial® intrapenile hyaluronic acid injections
- Protocol: 10–12 weekly sessions performed by Consultant Urologists
- Procedure Time: 20–30 minutes under local anaesthetic block
- Pricing: Initial Consultation: £180 | Treatment Injections: £250 per session (all-inclusive)
- Recovery: Same-day return to light daily activities; 24–48 hours rest from sexual and strenuous activity.
What is Peyronie’s Disease?
Peyronie’s disease — medically known as induratio penis plastica (IPP) — is an acquired condition where non-cancerous fibrous scar tissue (plaque) forms on the inner lining of the penis (tunica albuginea).
This scar tissue gradually reduces the elasticity of the penile shaft, leading to:
- Progressive penile curvature, causing the penis to appear bent or curved during an erection.
- Penile pain, particularly during the early or active phase.
- Palpable hard lumps or plaques along the shaft.
Peyronie’s disease can affect sexual function, cause discomfort and lead to emotional distress, particularly where symptoms such as penile pain or curvature continue to progress.
Peyronie’s Disease Treatment with Perovial® Injections
Northway Clinic offers Perovial®, an innovative, clinically proven intrapenile injection specifically designed for adult men in the acute (active) phase of Peyronie’s disease.
Northway Clinic offers Peyronie’s disease treatment in London using Perovial®, an intrapenile hyaluronic acid injection designed for adult men in the acute (active) phase of Peyronie’s disease.
How Perovial® Injections Work
Perovial® consists of a highly purified, medical-grade hyaluronic acid solution. Hyaluronic acid is naturally present in connective tissue, including the tunica albuginea.
When injected directly into the non-calcified plaque, Perovial®:
- Softens the fibrous plaque by retaining hydration within the matrix.
- Exerts antioxidant and anti-fibrotic actions, helping to reduce inflammation caused by tissue trauma.
- Helps limit plaque growth and alleviate pain, with the aim of slowing the progression of penile curvature.
Who is Suitable for Peyronie’s Disease Injection Treatment?
Treatment may be considered during the acute phase of the condition — typically within the first 6 to 12 months of symptom onset and before the plaque becomes calcified.
Who Can Benefit?
Perovial® treatment may be considered for:
- Men experiencing penile pain.
- Men noticing progressive penile curvature.
- Men who have recently developed palpable plaques.
Who May Not Be Suitable?
Perovial® is not suitable for everyone. Treatment is contraindicated in cases of:
- Stable, chronic-phase Peyronie’s disease with significant plaque calcification.
- Predominant hourglass deformity (unless specifically evaluated for pain management alone).
- Active infections of the skin, foreskin, genital area or urinary tract, such as urethritis.
- Known allergies or hypersensitivity to hyaluronic acid sodium salt.
Your Consultant Urologist will assess your symptoms, medical history and stage of Peyronie’s disease to determine whether Perovial® injections are suitable for you.
What to Expect During Peyronie’s Disease Treatment
At Northway Clinic, every step of your care is managed directly by experienced Consultant Urologists certified in the administration of Perovial®.
1. Pre-Treatment Assessment (£180)
Your consultant will carry out a detailed medical evaluation, review your surgical history, check any medications, such as blood thinners, and perform a physical examination or Doppler ultrasound review if required.
2. Local Anaesthetic and Pain Management
Each session takes approximately 20 to 30 minutes. A dorsal penile nerve block (local anaesthetic) is administered at the base of the penis before the procedure to help minimise discomfort during treatment.
3. Perovial® Injection Protocol (£250 per Injection, All-Inclusive)
- Standard Course: A course of 10 to 12 weekly injections.
- Technique: Using a sterile, single-use, prefilled device, your urologist will locate the plaque through manual palpation and infiltrate the solution directly into the target scar tissue.
- Post-Injection Massage: The urologist will apply a gentle 30 to 60-second manual massage to help distribute the hyaluronic acid throughout the plaque.
- All-Inclusive Fee: The £250 per-injection fee covers the prefilled Perovial® medication device, local anaesthesia, consumables, nursing assistance and consultant fees.
4. Recovery and Aftercare
Most patients can return to light daily activities immediately after their session. However, you should observe the following recovery guidelines:
- Rest: Avoid sexual activity and intense physical exercise for 24 to 48 hours following each injection.
- Clinic Stay: We recommend relaxing in our waiting room for 15 to 20 minutes after treatment to ensure you feel well before driving or heading home.
- No Ice: Do not apply ice packs to the penis before or after treatment.
- Traction Therapy: Your urologist may recommend an approved penile traction device to complement your injection treatment.
5. Follow-Up After Treatment
Following your 10–12 week course:
- First Review: Scheduled 4 to 6 weeks after completing your injection series.
- Second Review: Scheduled 3 to 4 months post-treatment for longer-term evaluation.
Peyronie’s Disease Treatment Cost
| Service / Stage | Cost | Description |
| Initial Urology Consultation | £180 | Full assessment, clinical history, plaque palpation and personalised treatment planning. |
| Perovial® Intrapenile Injection | £250 per session | All-inclusive cost covering medication, local nerve block, consultant administration and clinic fees. |
| Complete 10–12 Session Protocol | £2,500–£3,000 | Total course cost for the standard 10 to 12 weekly injection cycle. |
Perovial® Injection Risks and Side Effects
Perovial® injections are generally well tolerated. Potential side effects at the injection site may include:
- Mild tenderness, aching or soreness
- Temporary redness, heat or mild swelling
- Minor bruising or a small haematoma
- Brief, temporary changes in penile skin sensitivity
Your Consultant Urologist will discuss the potential risks and side effects of treatment with you before proceeding.
Peyronie’s Disease Treatment FAQs
Do I need a general anaesthetic for Perovial® injections?
No. The procedure is performed in our outpatient clinic under a targeted local anaesthetic block at the base of the penis, ensuring you remain comfortable throughout. The local block is included in the £250 injection fee.
Can I perform my first injection during my initial consultation?
Yes, if clinically appropriate and agreed upon between you and your Consultant Urologist during your baseline assessment.
What happens if I miss a weekly injection?
Gaps between injections should be avoided to maintain therapeutic effectiveness. Unavoidable delays must be limited to a maximum of one week.
Do I need to stop taking my regular medication?
Aspirin generally does not need to be stopped. If you take prescription blood thinners or anticoagulants, your urologist will conduct an individual risk assessment prior to commencing therapy.
Book a Peyronie’s Disease Consultation in London
If you have recently noticed penile curvature, pain or a firm plaque along the shaft, book a private Peyronie’s disease consultation in London with one of our Consultant Urologists.
Your consultant can assess your symptoms, discuss the stage of your condition and advise whether Perovial® injections or another approach may be appropriate for you.
